Targeting neuropilin-1 to inhibit prostate cancer invasion and metastasis

Volpert, Marianna, Tse, Brian W.C., Stylianou, Nataly, Ratther, Ellca, McPherson, Stephen, Costa, Taylor, McGowan, Kayla, Lehman, Melanie, Fazli, Ladan, Gleave, Martin, Russell, Pamela, Gunter, Jennifer H., Williams, Elizabeth D., Nelson, Colleen, & Hollier, Brett G. (2015) Targeting neuropilin-1 to inhibit prostate cancer invasion and metastasis. In 2nd Prostate Cancer World Congress, 17-21 August 2015, Cairns Convention Centre, Cairns, Qld.

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Abstract

Recent reports provide evidence that the epithelial-to-mesenchymal transition (EMT) plays a key role in prostate cancer (PCa) metastasis and therapy resistance. We have recently identified the cell surface receptor, Neuropilin-1 (NRP1) to be increased during epithelial-mesenchymal transition (EMT) and this study aims to determine whether the inhibition of NRP1 will be a feasible therapeutic strategy for blocking PCa metastasis and therapy resistance.

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ID Code: 94827
Item Type: Conference Item (Other)
Refereed: Yes
Keywords: neuropilin-1, prostate cancer, cancer invasion, metastasis
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Molecular Targets (111207)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 The Author(s)
Deposited On: 14 Apr 2016 03:00
Last Modified: 14 Apr 2016 03:02

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