Heritability of brain network topology in 853 twins and siblings

Zhan, L., Jahanshad, N., Faskowitz, J., Zhu, D., Prasad, G., Martin, N.G., de Zubicaray, G.I., McMahon, K.L., Wright, M.J., & Thompson, P.M. (2015) Heritability of brain network topology in 853 twins and siblings. In 12th IEEE International Symposium on Biomedical Imaging (ISBI 2015), 16-19 April 2015, Brooklyn, NY.

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Anatomical brain networks change throughout life and with diseases. Genetic analysis of these networks may help identify processes giving rise to heritable brain disorders, but we do not yet know which network measures are promising for genetic analyses. Many factors affect the downstream results, such as the tractography algorithm used to define structural connectivity. We tested nine different tractography algorithms and four normalization methods to compute brain networks for 853 young healthy adults (twins and their siblings). We fitted genetic structural equation models to all nine network measures, after a normalization step to increase network consistency across tractography algorithms. Probabilistic tractography algorithms with global optimization (such as Probtrackx and Hough) yielded higher heritability statistics than 'greedy' algorithms (such as FACT) which process small neighborhoods at each step. Some global network measures (probtrackx-derived GLOB and ST) showed significant genetic effects, making them attractive targets for genome-wide association studies.

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3 citations in Scopus
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ID Code: 94877
Item Type: Conference Paper
Refereed: Yes
Keywords: diffusion MRI, brain network, tractography, ICC, normalization
DOI: 10.1109/ISBI.2015.7163908
ISBN: 9781479923748
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2015 IEEE
Deposited On: 15 Apr 2016 02:38
Last Modified: 19 Apr 2016 17:40

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