Is there a role for microsampling in antibiotic pharmacokinetic studies?
Parker, Suzanne L., Dorofaeff, Tavey, Lipman, Jeffrey, Ballot, Daynia E., Bandini, Rossella M., Wallis, Steven C., & Roberts, Jason A. (2016) Is there a role for microsampling in antibiotic pharmacokinetic studies? Expert Opinion on Drug Metabolism & Toxicology, 12(6), pp. 601-614.
- Clinical pharmacokinetic studies of antibiotics can establish evidence-based dosing regimens that improve the likelihood of eradicating the pathogen at the site of infection, reduce the potential for selection of resistant pathogens, and minimize harm to the patient. Innovations in small volume sampling (< 50 μL) or ‘microsampling’ may result in less-invasive sample collection, self-sampling and dried storage. Microsampling may open up opportunities in patient groups where sampling is challenging.
- The challenges for implementation of microsampling to assure suitability of the results, include: acceptable study design, regulatory agency acceptance, and meeting bioanalytical validation requirements. This manuscript covers various microsampling methods, including dried blood/plasma spots, volumetric absorptive microsampling, capillary microsampling, plasma preparation technologies and solid-phase microextraction.
- The available analytical technology is being underutilized due to a lack of bridging studies and validated bioanalytical methods. These deficiencies represent major impediments to the application of microsampling to antibiotic pharmacokinetic studies. A conceptual framework for the assessment of the suitability of microsampling in clinical pharmacokinetic studies of antibiotics is provided. This model establishes a ‘contingency approach’ with consideration of the antibiotic and the type and location of the patient, as well as the more prescriptive bioanalytical validation protocols.
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|Item Type:||Journal Article|
|Keywords:||microsampling, pharmacokinetic, antibiotic|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NURSING (111000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500)
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Nursing
|Copyright Owner:||Copyright 2016 Taylor & Francis|
|Deposited On:||20 Apr 2016 22:40|
|Last Modified:||17 Aug 2016 00:39|
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