CDCA3 regulates the cell cycle and modulates cisplatin sensitivity in non-small cell lung cancer

O'Byrne, K., Adams, M., Burgess, J., & Richard, D. (2016) CDCA3 regulates the cell cycle and modulates cisplatin sensitivity in non-small cell lung cancer. In European Lung Cancer Conference (ELCC 2016), 13 - 16 April 2016, Geneva, Switzerland.

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Abstract

Cisplatin-based regimens are currently the most effective chemotherapy for non-small cell lung cancer (NSCLC). Cisplatin forms DNA crosslinks to stall DNA replication and induce apoptosis. However, intrinsic and acquired chemoresistance is a major therapeutic problem. We have identified ‘cell division cycle associated protein 3’ (CDCA3) as a novel protein that may prove useful in delaying or preventing cisplatin resistance in NSCLC. CDCA3 functions as part of an ubiquitin ligase complex to degrade the endogenous cell cycle inhibitors. While a role for CDCA3 in disease is emerging with elevated expression noted in oral squamous cell carcinoma, little else is known about CDCA3 or whether this protein may prove useful clinically.

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ID Code: 95259
Item Type: Conference Item (Presentation)
Refereed: Yes
Additional Information: Abstract published in Journal of Thoracic Oncology, 11(4), Supplement, S65
Additional URLs:
DOI: 10.1016/S1556-0864(16)30138-1
ISSN: 1556-0864
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 29 Apr 2016 00:54
Last Modified: 29 Apr 2016 00:54

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