Lung cancer stem cells: The root of resistance

MacDonagh, Lauren, Gray, Steven G., Breen, Eamon, Cuffe, Sinead, Finn, Stephen P., O'Byrne, Kenneth J., & Barr, Martin P. (2016) Lung cancer stem cells: The root of resistance. Cancer Letters, 372(2), pp. 147-156.

View at publisher


In the absence of specific treatable mutations, platinum-based chemotherapy remains the gold standard of treatment for lung cancer patients. However, 5-year survival rates remain poor due to the development of resistance and eventual relapse. Resistance to conventional cytotoxic therapies presents a significant clinical challenge in the treatment of this disease. The cancer stem cell (CSC) hypothesis suggests that tumors are arranged in a hierarchical structure, with the presence of a small subset of stem-like cells that are responsible for tumor initiation and growth. This CSC population has a number of key properties such as the ability to asymmetrically divide, differentiate and self-renew, in addition to having increased intrinsic resistance to therapy. While cytotoxic chemotherapy kills the bulk of tumor cells, CSCs are spared and have the ability to recapitulate the heterogenic tumor mass. The identification of lung CSCs and their role in tumor biology and treatment resistance may lead to innovative targeted therapies that may ultimately improve clinical outcomes in lung cancer patients. This review will focus on lung CSC markers, their role in resistance and their relevance as targets for future therapies.

Impact and interest:

4 citations in Scopus
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 95330
Item Type: Journal Article
Refereed: Yes
Keywords: Lung cancer; Cancer stem cells; Chemotherapy; Resistance; Markers
DOI: 10.1016/j.canlet.2016.01.012
ISSN: 0304-3835
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 May 2016 23:00
Last Modified: 04 May 2016 05:21

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page