Clinician perspective on molecular profiling of non-small-cell lung cancer

Decatris, Marios P., Farrugia, David, & O'Byrne, Kenneth J. (2016) Clinician perspective on molecular profiling of non-small-cell lung cancer. Journal of Clinical Oncology, 34(8), pp. 884-886.

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Abstract

The article by Meric-Bernstam et al1 that was recently published in Journal of Clinical Oncology raises important questions about the clinical application of large-scale genomic testing. We congratulate the authors for this ambitious study, which successfully profiled 2,000 consecutive patients with advanced cancer. The next-generation sequencing (NGS) platform was used for 1,749 of 2,000 patients (87.5%). Of 789 patients with potentially actionable mutations, 83 (11%, or 4% of screened population) were enrolled in a genomically matched clinical study. As the editorial2 accompanying the article by Meric-Bernstam et al1 pointed out, the 4% figure, albeit disappointing, may be an underestimate because cancers such as lung adenocarcinoma and melanoma, for which ≥ 50% of patients have actionable mutations, were under-represented. ...

Impact and interest:

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ID Code: 95331
Item Type: Journal Article
Refereed: Yes
Keywords: NSCLC, adenocarcinoma, genomic testing, melanoma
DOI: 10.1200/JCO.2015.65.2040
ISSN: 1527-7755
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 May 2016 23:05
Last Modified: 04 May 2016 05:36

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