Clinician perspective on molecular profiling of non-small-cell lung cancer
Decatris, Marios P., Farrugia, David, & O'Byrne, Kenneth J. (2016) Clinician perspective on molecular profiling of non-small-cell lung cancer. Journal of Clinical Oncology, 34(8), pp. 884-886.
The article by Meric-Bernstam et al1 that was recently published in Journal of Clinical Oncology raises important questions about the clinical application of large-scale genomic testing. We congratulate the authors for this ambitious study, which successfully profiled 2,000 consecutive patients with advanced cancer. The next-generation sequencing (NGS) platform was used for 1,749 of 2,000 patients (87.5%). Of 789 patients with potentially actionable mutations, 83 (11%, or 4% of screened population) were enrolled in a genomically matched clinical study. As the editorial2 accompanying the article by Meric-Bernstam et al1 pointed out, the 4% figure, albeit disappointing, may be an underestimate because cancers such as lung adenocarcinoma and melanoma, for which ≥ 50% of patients have actionable mutations, were under-represented. ...
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|Item Type:||Journal Article|
|Keywords:||NSCLC, adenocarcinoma, genomic testing, melanoma|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||02 May 2016 23:05|
|Last Modified:||04 May 2016 05:36|
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