Epigenetics Underpinning DNA Damage Repair

Richard, Derek J., Bolderson, Emma, Baird, Anne-Marie, & O’Byrne, Kenneth J. (2015) Epigenetics Underpinning DNA Damage Repair. In Gray, Steven G. (Ed.) Epigenetic Cancer Therapy. Elsevier Inc., Amsterdam, pp. 595-612.

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Epigenetics is the study of heritable changes in gene expression that are not the result of genetic alterations. These changes include DNA methylation, histone modifications, or indeed microRNA expression. Chromatin is a tightly compacted DNA–protein complex that allows approximately two meters of DNA to be packaged inside a cell, only a few micrometers across. Although the resulting DNA structure is very stable, it is not very amiable to DNA-dependent processes, so mechanisms have to exist to allow processes such as transcription, replication, and DNA repair to occur. This chapter will look at how a cell responds to and deals with genomic instability at the epigenetic level and highlight how critical chromatin remodeling is for correct DNA repair and cell survival following DNA damage. This chapter will initially look at the DNA repair pathways that function in human cells and then at how the repair of DNA damage is controlled by epigenetics.

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ID Code: 95334
Item Type: Book Chapter
DOI: 10.1016/B978-0-12-800206-3.00025-2
ISBN: 9780128002063
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Elsevier Inc.
Deposited On: 02 May 2016 23:28
Last Modified: 04 May 2016 01:46

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