Detection of recently discovered human polyomaviruses in a longitudinal kidney transplant cohort

Bialasiewicz, S., Rockett, R.J., Barraclough, K.A., Leary, D., Dudley, K.J., Isbel, N.M., & Sloots, T.P. (2016) Detection of recently discovered human polyomaviruses in a longitudinal kidney transplant cohort. American Journal of Transplantation, 16(9), pp. 2734-2740.

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Abstract

A large number of human polyomaviruses have been discovered in the last 7 years. However, little is known about the clinical impact on vulnerable immunosuppressed patient populations. Blood, urine, and respiratory swabs collected from a prospective, longitudinal adult kidney transplant cohort (n = 167) generally pre-operatively, at day 4, months 1, 3, and 6 posttransplant, and at BK viremic episodes within the first year were screened for 12 human polyomaviruses using real-time polymerase chain reaction. Newly discovered polyomaviruses were most commonly detected in the respiratory tract, with persistent shedding seen for up to 6 months posttransplant. Merkel cell polyomavirus was the most common detection, but was not associated with clinical symptoms or subsequent development of skin cancer or other skin abnormalities. In contrast, KI polyomavirus was associated with respiratory disease in a subset of patients. Human polyomavirus 9, Malawi polyomavirus, and human polyomavirus 12 were not detected in any patient samples.

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ID Code: 95457
Item Type: Journal Article
Refereed: Yes
DOI: 10.1111/ajt.13799
ISSN: 1600-6135
Divisions: Current > Schools > School of Earth, Environmental & Biological Sciences
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons
Deposited On: 10 May 2016 01:33
Last Modified: 23 Sep 2016 00:02

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