The emerging world of small ORFs

Hellens, Roger P., Brown, Chris M., Chisnall, Matthew A.W., Waterhouse, Peter M., & Macknight, Richard C. (2016) The emerging world of small ORFs. Trends in Plant Science, 21(4), pp. 317-328.

View at publisher


Small open reading frames (sORFs) are an often overlooked feature of plant genomes. Initially found in plant viral RNAs and considered an interesting curiosity, an increasing number of these sORFs have been shown to encode functional peptides or play a regulatory role. The recent discovery that many of these sORFs initiate with start codons other than AUG, together with the identification of functional small peptides encoded in supposedly noncoding primary miRNA transcripts (pri-miRs), has drastically increased the number of potentially functional sORFs within the genome. Here we review how advances in technology, notably ribosome profiling (RP) assays, are complementing bioinformatics and proteogenomic methods to provide powerful ways to identify these elusive features of plant genomes, and highlight the regulatory roles sORFs can play.

Impact and interest:

0 citations in Scopus
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 95508
Item Type: Journal Article
Refereed: Yes
Keywords: Translation, Small open reading frame, Upstream open reading frame, Ribosome profiling, Non-AUG translation initiation
DOI: 10.1016/j.tplants.2015.11.005
ISSN: 1360-1385
Divisions: Current > Research Centres > Centre for Tropical Crops and Biocommodities
Current > Schools > School of Earth, Environmental & Biological Sciences
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: 2015 Elsevier Ltd
Deposited On: 12 May 2016 03:41
Last Modified: 13 May 2016 01:24

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page