An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys
Cano, Jorge, Moraga, Paula, Nikolay, Birgit, Rebollo, Maria P., Okorie, Patricia N., Davies, Emmanuel, Njenga, Sammy M., Bockarie, Moses J., & Brooker, Simon J. (2015) An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys. Transactions of The Royal Society of Tropical Medicine and Hygiene, 109(8), pp. 529-531.
The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.
This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.
Results and Conclusions
In some settings there was a very large disparity, up to 40–70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.
Impact and interest:
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|Item Type:||Journal Article|
|Keywords:||Antigenaemia, Logistic regression, Lymphatic filariasis, Microfilaraemia, Prevalence surveys|
|Divisions:||Current > Research Centres > ARC Centre of Excellence for Mathematical & Statistical Frontiers (ACEMS)
Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2015 The Author|
|Copyright Statement:||This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Deposited On:||23 May 2016 02:33|
|Last Modified:||23 May 2016 21:46|
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