An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys

Cano, Jorge, Moraga, Paula, Nikolay, Birgit, Rebollo, Maria P., Okorie, Patricia N., Davies, Emmanuel, Njenga, Sammy M., Bockarie, Moses J., & Brooker, Simon J. (2015) An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys. Transactions of The Royal Society of Tropical Medicine and Hygiene, 109(8), pp. 529-531.

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The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.


This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.

Results and Conclusions

In some settings there was a very large disparity, up to 40–70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.

Impact and interest:

3 citations in Scopus
3 citations in Web of Science®
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ID Code: 95688
Item Type: Journal Article
Refereed: Yes
Keywords: Antigenaemia, Logistic regression, Lymphatic filariasis, Microfilaraemia, Prevalence surveys
DOI: 10.1093/trstmh/trv048
ISSN: 1878-3503
Divisions: Current > Research Centres > ARC Centre of Excellence for Mathematical & Statistical Frontiers (ACEMS)
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2015 The Author
Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Deposited On: 23 May 2016 02:33
Last Modified: 27 Jun 2017 20:01

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