The use and risks of antibiotics in critically ill patients

Denny, Kerina J., Cotta, Menino O., Parker, Suzanne L., Roberts, Jason A., & Lipman, Jeffrey (2016) The use and risks of antibiotics in critically ill patients. Expert Opinion on Drug Safety, 15(5), pp. 667-678.

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Introduction: The altered pathophysiology in critically ill patients presents a unique challenge in both the diagnosis of infection and the appropriate prescription of antibiotics. In this context, the importance of effective and timely treatment needs to be weighed against the individual and community harms associated with antibiotic collateral damage and antibiotic resistance.

Areas Covered: We evaluate the principles of antibiotic use in critically ill patients, including dose optimisation, use of combination antibiotic therapy, therapeutic drug monitoring, appropriate antibiotic therapy duration, de-escalation, and utilisation of sepsis biomarkers. We also describe the potential risks associated with antibiotic therapy including antibiotic resistance, delayed treatment, treatment failure, and collateral damage.

Expert Opinion: Prescribing teams must be aware of the impact of critical illness on their patients and tailor antibiotic therapy appropriately to prevent the significant harms associated with suboptimal antibiotic administration.

Impact and interest:

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ID Code: 95721
Item Type: Journal Article
Refereed: Yes
Keywords: Antibiotics, critical illness, infection, resistance, sepsis
DOI: 10.1517/14740338.2016.1164690
ISSN: 1744-764X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NURSING (111000)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Nursing
Copyright Owner: Copyright 2016 Taylor & Francis
Deposited On: 23 May 2016 22:50
Last Modified: 17 Aug 2016 00:34

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