Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: By sex status

Zhou, Yang, Hu, Li-Wen, Qian, Zhengmin (Min), Chang, Jen-Jen, King, Chris, Paul, Gunther, Lin, Shao, Chen, Pau-Chung, Lee, Yungling Leo, & Dong, Guang-Hui (2016) Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: By sex status. Environment International, 94, pp. 189-195.

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Abstract

Polyfluoroalkyl substances (PFASs) are a group of common chemicals that ubiquitously exist in wildlife and humans. However, few studies have researched the effect of PFASs on reproductive hormones in adolescents. To provide information in this regard, we recruited 225 Taiwanese adolescents aged 13-15 years from 2009 to 2010 to investigate the relationship between serum PFASs (PFOS, PFOA, PFBS, PFDA, PFDoA, PFHxA, PFHxS, PFNA and PFTA) and reproductive hormone concentrations using a cross-sectional study design. Results showed PFOS and PFTA levels were highest among the PFASs, with a median concentrations of 29.9 (interquartile range: 13.0-43.8) ng/mL and 6.0 (0.6-25.9) ng/mL in males, and a median concentrations of 28.8 (14.8-42.6) ng/mL and 4.5 (0.3-18.4) ng/mL in females. After adjustment for confounding factors, nonsignificant associations between PFASs and reproductive hormone were found except for PFNA with ln(estradiol) (β=0.2060, 95%CI: 0.0016, 0.4105). When stratified by sex, more significant associations were found in males than in females. Among males, PFASs were negatively associated with ln(testosterone) level for PFOS (β=-0.0029, 95%CI: -0.0055, - 0.0003), PFDA (β=-0.2565, 95%CI: -0.4135,-0.0994), PFHxA (β=-0.3095, 95%CI: -0.5942,-0.0248), and PFNA (β=-0.4233, 95%CI:-0.6998, -0.1467). Furthermore, male participant ln(estradiol) levels were positively associated with PFOA (β=0.0921, 95%CI: 0.0186, 0.1656), and PFHxS (β=0.0462, 95%CI: 0.0020, 0.0905). Among females, a significant relationship was found only for PFDoA with ln(testosterone)(β=-0.0119, 95%CI: -0.0227, -0.0010). In conclusion, this study showed higher levels of PFASs coincide with lower testosterone and higher estradiol levels, and more significant associations of PFASs with reproductive hormone were found in males than in females.

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ID Code: 95732
Item Type: Journal Article
Refereed: Yes
Keywords: Perfluoroalkyl substances, Testosterone, Estradiol, Sex, Adolescents
DOI: 10.1016/j.envint.2016.05.018
ISSN: 0160-4120
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Environmental and Occupational Health and Safety (111705)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
Funding:
  • NNSF CHINA/81472936
  • NNSF CHINA/81172630
  • FRFCU/16ykzd02
  • NSC TAIWAN/98-2314-B- 16 002-138-MY3
  • NSC TAIWAN/101-2621-M-002-005
Copyright Owner: Copyright 2016 Elsevier Ltd.
Deposited On: 06 Jun 2016 22:26
Last Modified: 10 Jun 2016 13:13

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