In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146

Ong, Vanissa A., Lawrence, Amba, Timms, Peter, Vodstrcil, Lenka A., Tabrizi, Sepehr N., Beagley, Kenneth, Allan, John, Hocking, Jane S., & Huston, Wilhelmina M. (2015) In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146. Microbes and Infection, 17(11-12), pp. 738-744.

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Abstract

The present study aimed to establish if a previously identified Chlamydia trachomatis HtrA (CtHtrA) inhibitor, JO146, is effective against currently circulating clinical isolates to validate if CtHtrA is a clinically relevant target for future therapeutic development. Inhibition of CtHtrA during the middle of the chlamydial replicative cycle until the completion of the cycle resulted in loss of infectious progeny for six unique clinical isolates representing different serovars. This supports the potential for CtHtrA to be a clinically relevant target for development of new therapeutics and suggests the importance of further investigation of JO146 as a lead compound.

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ID Code: 95792
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Chlamydia, clinical isolate, HtrA, inhibitor
DOI: 10.1016/j.micinf.2015.09.004
ISSN: 1286-4579
Divisions: Current > Schools > School of Biomedical Sciences
Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Funding:
Copyright Owner: 2015 Institut Pasteur. Published by Elsevier Masson SAS
Copyright Statement: Licensed under the Creative Commons Attribution; Non-Commercial; No-Derivatives 4.0 International. DOI: 10.1016/j.micinf.2015.09.004
Deposited On: 26 May 2016 22:49
Last Modified: 07 Dec 2016 04:05

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