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Elution and mechanical properties of antifungal bone cement

Goss, Benjamin G., Lutton, Cameron J., Weinrauch, Patrick C., Jabur, Majid, Gillett, Greg, & Crawford, Ross W. (2007) Elution and mechanical properties of antifungal bone cement. Journal of Arthroplasty, 22(6), pp. 902-908.

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Abstract

The effect of the incorporation of amphotericin B into bone cement was examined; as literature suggests, this may be a feasible method for the treatment of periprosthetic fungal infections. Addition of antifungal increased the compressive strength of the bone cement-a statistically significant amount from 107 +/- 2.3 to 121 +/- 1.5 MPa. Elution of tobramycin and amphotericin B was quantified using ultraviolet-visible spectroscopy. Spectroscopy showed that 18% of the antibiotic was released during the first week, with most released in the first 24 hours. The elution of antifungal, however, was unable to be detected after 1 week, with less than 0.03% released. Amphotericin B does not weaken bone cement. Its inability to be delivered at a clinically significant dose gives no clear indication for its incorporation into cement.

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23 citations in Scopus
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15 citations in Web of Science®

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ID Code: 9597
Item Type: Journal Article
Additional Information: For more information, please refer to the journal's website (see hypertext link) or contact the author.
Keywords: Fungal infection, bone cement, amphotericin B release
DOI: 10.1016/j.arth.2006.09.013
ISSN: 0883-5403
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Orthopaedics (110314)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Elsevier
Deposited On: 19 Sep 2007
Last Modified: 29 Feb 2012 23:36

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