Multi-elemental profiling of tibial and maxillary trabecular bone in ovariectomised rats

Han, Pingping, Lu, Shifeier, Zhou, Yinghong, Moromizato, Krine, Du, Zhibin, Friis, Thor, & Xiao, Yin (2016) Multi-elemental profiling of tibial and maxillary trabecular bone in ovariectomised rats. International Journal of Molecular Sciences, 17(6), Article Number-977.

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Abstract

Atomic minerals are the smallest components of bone and the content of Ca, being the most abundant mineral in bone, correlates strongly with the risk of osteoporosis. Postmenopausal women have a far greater risk of suffering from OP due to low Ca concentrations in their bones and this is associated with low bone mass and higher bone fracture rates. However, bone strength is determined not only by Ca level, but also a number of metallic and non-metallic elements in bone. Thus, in this study, the difference of metallic and non-metallic elements in ovariectomy-induced osteoporosis tibial and maxillary trabecular bone was investigated in comparison with sham operated normal bone by laser ablation inductively-coupled plasma mass spectrometry using a rat model. The results demonstrated that the average concentrations of 25Mg, 28Si, 39K, 47Ti, 56Fe, 59Co, 77Se, 88Sr, 137Ba, and 208Pb were generally higher in tibia than those in maxilla. Compared with the sham group, Ovariectomy induced more significant changes of these elements in tibia than maxilla, indicating tibial trabecular bones are more sensitive to changes of circulating estrogen. In addition, the concentrations of 28Si, 77Se, 208Pb, and Ca/P ratios were higher in tibia and maxilla in ovariectomised rats than those in normal bone at all time-points. The present study indicates that ovariectomy could significantly impact the element distribution and concentrations between tibia and maxilla.

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ID Code: 95988
Item Type: Journal Article
Refereed: Yes
Additional Information: This article belongs to the Special Issue Molecular Research on Dental Materials and Biomaterials.
Keywords: ovariectomised rats, tibia, maxilla, LA-ICP-MS, osteoporosis
DOI: 10.3390/ijms17060977
ISSN: 1422-0067
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2016 by the authors; licensee MDPI, Basel, Switzerland.
Copyright Statement: This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
Deposited On: 22 Jun 2016 22:02
Last Modified: 23 Jun 2016 23:44

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