Time course of changes in goblet cell density in symptomatic and asymptomatic contact lens wearers

Colorado, Luisa H., Alzahrani, Yahya, Pritchard, Nicola, & Efron, Nathan (2016) Time course of changes in goblet cell density in symptomatic and asymptomatic contact lens wearers. Investigative Ophthalmology and Visual Science, 57, pp. 2888-2894.

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Purpose: To investigate longitudinal changes in goblet cell density (GCD) in contact lens (CL) wearers who do and do not develop symptoms of dry eye (DE).

Methods: Sixty healthy individuals fitted with daily disposable hydrogel CLs and 23 age-balanced non-CL–wearing controls underwent assessment using the 5-item dry eye questionnaire, noninvasive tear film break-up time measurement, ocular surface assessment, and phenol red thread test evaluation. Laser scanning confocal microscopy (LSCM) and conjunctival impression cytology (CIC) were used to assess GCD at baseline and follow-up visits at 1 week and 1 and 6 months. After 1 week, all CL wearers were categorized as those who were and were not symptomatic based on responses to the CL dry eye questionnaire-8 (CLDEQ-8). A linear mixed-model was used to examine changes in GCD over time.

Results: The global mean GCD of the 83 participants at baseline (before CL wear) was 476 ± 41 and 467 ± 52 cells/mm2 using LSCM and CIC, respectively. After 6 months of CL wear, GCD was reduced by approximately 13% and 29% in asymptomatic (N = 29) and symptomatic (N = 17) CL wearers (all P < 0.001), respectively, observed with both LSCM and CIC.

Conclusions: Contact lens wear induces a reduction of GCD over 6 months, which is exacerbated in those with DE symptoms. Either LSCM or CIC can be used to assess GCD in the conjunctiva.

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1 citations in Web of Science®
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ID Code: 96062
Item Type: Journal Article
Refereed: Yes
Keywords: conjunctival goblet cells, contact lens wear, symptoms, dry eye
DOI: 10.1167/iovs.16-19298
ISSN: 1552-5783
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2016 The authors
Copyright Statement: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
Deposited On: 13 Jun 2016 22:25
Last Modified: 13 Jun 2016 22:25

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