[Conference abstract] Do seasons affect Parkinson's disease: Empirical examination from Australia

Rowell, David, Nghiem, Hong Son, Subramarian, Hari, & Silburn, Peter (2015) [Conference abstract] Do seasons affect Parkinson's disease: Empirical examination from Australia. Journal of the Neurological Sciences, 357(Supplement 1), e81.

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Background: Seasonal fluctuation in striatal dopamine has been documented in people with Parkinson's disease (PD), however variation in clinical signs and symptoms have not yet been identified. No research has sought to identify the root causes of any seasonal change in PD.

Objective: To test what effect seasonal changes the weather may have on PD.

Patients and methods/material and methods: 23 years of monthly data from the Australian Pharmaceutical Benefits Scheme and Bureau of Meteorology were obtained for eight Australian states and territories. The dependent variable, the national levodopa equivalent dose (LED) was aggregated from 50 PD medications. Three elements of weather, temperature (°C), relative humidity (%) and solar intensity (Mj/m2) were analysed. The relationships are tested using linear and non-linear (Cosinor) regression with fixed and random effects, respectively.

Results: Temperature and relative humidity were positively correlated with the national LED. However, their effect on LED was seasonally opposed. Solar intensity had no effect on LED.

Conclusion: A better understanding of the causes of seasonal variation in PD may help clinicians and patients better manage this chronic disease.

Impact and interest:

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ID Code: 96229
Item Type: Journal Article
Refereed: Yes
Additional Information: Abstracts from the World Congress of Neurology (WCN 2015)
DOI: 10.1016/j.jns.2015.08.283
ISSN: 0022-510X
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
Copyright Owner: Copyright © 2015 Published by Elsevier B.V.
Deposited On: 16 Jun 2016 23:40
Last Modified: 19 Jun 2016 21:41

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