Investigating the role of a novel epigenetic modifier, rearranged L-Myc fusion, in the mouse

Bourke, Lauren M. (2016) Investigating the role of a novel epigenetic modifier, rearranged L-Myc fusion, in the mouse. PhD thesis, Queensland University of Technology.


Rearranged L-Myc Fusion, Rlf, was recently identified as a novel epigenetic modifier from a mouse N-ethyl-N-nitrosourea mutagenesis screen. The mice used carry a multi-copy green fluorescent protein transgene that is sensitive to epigenetic silencing. Three independent mouse lines, MommeD8, MommeD28 and MommeD34, with mutations in Rlf were each found to have decreases in the percentage of red blood cells expressing GFP, suggesting Rlf acts an epigenetic modifier and plays a role in transcriptional activation. The results presented in this study indicate Rlf plays an important role in heart and inactivation of Rlf alters the transcriptome, methylome and phenotype in the mouse.

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ID Code: 96248
Item Type: QUT Thesis (PhD)
Supervisor: Pollock, Pamela, Herington, Adrian, Khanna, Kum, & Harten, Sarah
Keywords: epigenetics, Rearranged L-Myc Fusion, heart dvelopment, methylation, gene transcription
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 14 Jul 2016 00:44
Last Modified: 14 Jul 2016 00:44

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