Nucleophosmin and genomic stability
Hoad, Bradley W. (2016) Nucleophosmin and genomic stability. PhD thesis, Queensland University of Technology.
Cancer is caused by a loss of genomic stability. Once cancer forms genomic instability allows it to adapt to the environment, metastasise and become resistant to therapeutics. DNA damage poses a constant threat to genomic integrity with the action of nucleases, oxidation, ionising radiation and radio-mimetic chemicals causing an array of DNA lesions. NPM1 has recently been implicated in the processes of DNA repair. The data I present provides evidence of a novel role for NPM1 in DNA repair and specifically in the homologous repair pathway. NPM1 mutation is commonly associated with acute myeloid leukaemia. This thesis describes the deficient genomic stability mechanisms this form of leukaemia exploits to promote the progression of the disease, a novel discovery which may potentially change current treatment approaches.
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|Item Type:||QUT Thesis (PhD)|
|Supervisor:||Richard, Derek & O'Byrne, Ken|
|Keywords:||Nucleophosmin, NPM1, Cancer, Genomic, Stability, Cancer|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Institution:||Queensland University of Technology|
|Deposited On:||14 Jul 2016 00:48|
|Last Modified:||14 Jul 2016 00:48|
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