Retinal tissue thickness is reduced in diabetic peripheral neuropathy

Srinivasan, Sangeetha, Pritchard, Nicola, Vagenas, Dimitrios, Edwards, Katie, Sampson, Geoff P., Russell, Anthony W., Malik, Rayaz A., & Efron, Nathan (2016) Retinal tissue thickness is reduced in diabetic peripheral neuropathy. Current Eye Research. (In Press)

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Aim: To investigate the relationship between diabetic peripheral neuropathy (DPN) and retinal tissue thickness.

Methods: Full retinal thickness in the central retinal, parafoveal, and perifoveal zones and thickness of the ganglion cell complex and retinal nerve fiber layer (RNFL) were assessed in 193 individuals (84 with type 1 diabetes, 67 with type 2 diabetes, and 42 healthy controls) using spectral domain optical coherence tomography. Among those with diabetes, 44 had neuropathy defined using a modified neuropathy disability score recorded on a 0–10 scale. Multiple regression analysis was performed to investigate the relationship between diabetic neuropathy and retinal tissue thickness, adjusted for the presence of diabetic retinopathy (DR), age, sex, duration of diabetes, and HbA1c levels.

Results: In individuals with diabetes, perifoveal thickness was inversely related to the severity of neuropathy (p < 0.05), when adjusted for age, sex, duration of diabetes, and HbA1c levels. DR was associated with reduced thickness in parafovea (p < 0.01). The RNFL was thinner in individuals with greater degrees of neuropathy (p < 0.04).

Conclusions: DPN is associated with structural compromise involving several retinal layers. This compromise may represent a threat to visual integrity and therefore warrants examination of functional correlates.

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ID Code: 96403
Item Type: Journal Article
Refereed: Yes
Keywords: Diabetic peripheral neuropathy, ganglion cell complex, neuropathy disability score, retinal nerve fiber layer, retinal thickness
DOI: 10.3109/02713683.2015.1119855
ISSN: 1460-2202
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2016 Taylor & Francis
Deposited On: 28 Jun 2016 22:44
Last Modified: 12 Jul 2016 00:30

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