Potential clinical efficacy of the 10-valent pneumococcal-Protein D conjugate vaccine in children with chronic suppurative lung diseases: A double-blind randomised controlled trial
O'Grady, Kerry-Ann, Grimwood, Keith, Cripps, Allan W., Mulholland, E. Kim, Smith-Vaughan, Heidi, Danchin, Margaret, Wood, Nicholas, Wilson, Andrew, Thornton, Ruth, Torzillo, Paul J., Morris, Peter, Richmond, Peter, Perrett, Kirsten, Rablin, Sheree, Connor, Anne, Goyal, Vikas, Stoney, Tanya, & Chang, Anne B. (2016) Potential clinical efficacy of the 10-valent pneumococcal-Protein D conjugate vaccine in children with chronic suppurative lung diseases: A double-blind randomised controlled trial. In 10th International Symposium on Pneumococci & Pneumococcal Diseases, 26-30 June 2016, Glasgow, Scotland. (Unpublished)
• Chronic suppurative lung diseases (CSLD) in children are important causes of morbidity and recurrent acute exacerbations are associated with long term lung function decline.
• Non-‐typeable H. influenzae (NTHi) and S. pneumoniae are commonly isolated from the lower airways of both children and adults with CSLD.
• The potential clinical impact of a non-‐typeable Haemophilus influenzae (NTHi) vaccine in children with CSLD has not been investigated.
• We aimed to determine the clinical efficacy of the 10-‐valent pneumococcal-‐Protein D conjugate vaccine (10vPHiD-‐CV) in children aged 18-‐months to <18-‐years with CSLD (Immunogenicity data are presented in Poster xxx). Primary clinical objective.
• Determine the efficacy of 10vPHiD-‐CV in reducing the incidence of acute exacerbations in the 12-‐months following the 2nd dose of study vaccine. Secondary clinical objectives.
• Determine the efficacy of 10vPHiD-‐CV in reducing the incidence of any parent/carer-‐reported respiratory symptoms in the 12 months following the second dose of study vaccine.
• Determine the efficacy of 10vPHiD-‐CV in reducing antibiotic use in the 12 months following the second dose of study vaccine.
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|Item Type:||Conference Item (Poster)|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
|Copyright Owner:||Copyright 2016 The Author(s)|
|Deposited On:||30 Jun 2016 00:57|
|Last Modified:||30 Jun 2016 00:57|
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