Retinal tissue thickness in type 1 and type 2 diabetes

Srinivasan, Sangeetha, Pritchard, Nicola, Sampson, Geoff P., Edwards, Katie P., Vagenas, Dimitrios, Russell, Anthony W., Malik, Rayaz A., & Efron, Nathan (2016) Retinal tissue thickness in type 1 and type 2 diabetes. Clinical and Experimental Optometry, 99(1), pp. 78-83.

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  • The objective was to investigate full retinal and inner retinal thickness in individuals with type 1 and type 2 diabetes.


  • Eighty-four individuals with type 1 diabetes (T1DM), 67 individuals with type 2 diabetes (T2DM) and 42 non-diabetic individuals (control group) were enrolled. Participants underwent full retinal thickness evaluation in the central retinal, parafoveal and perifoveal zones and in the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC), using spectral domain optical coherence tomography. As a preliminary step, the key variables of interest - age, sex, diabetic retinopathy (DR), duration of diabetes and HbA1c levels - were analysed and compared between the three groups. Full retinal thickness, RNFL and GCC thicknesses were also compared between the groups. The relationship between the type of diabetes and retinal tissue thickness was explored, adjusting for the five potential confounders.


  • Compared to individuals with T1DM, individuals with T2DM had significantly reduced full retinal thickness in the parafovea and perifovea and reduced RNFL and GCC thickness. The mean differences were six (p = 0.020), seven (p = 0.008), six (p = 0.021) and four micrometres (p = 0.013) for the parafovea, perifovea, RNFL and GCC thicknesses, respectively. Thicknesses within the central zone (p = 0.018) and at the parafovea (p = 0.007) were significantly reduced in T2DM when compared to the control group. After adjusting for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels, the relationship between type of diabetes and retinal tissue thickness was not statistically significant (p > 0.056).


  • Retinal tissue thickness is not significantly different between type 1 and type 2 diabetes, when adjusted for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels.

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ID Code: 96568
Item Type: Journal Article
Refereed: Yes
Keywords: diabetic retinopathy; ;; type 2 diabetes, retinal thickness, retinal nerve fibre layer;, ganglion cell complex;, type 1 diabetes, type 1 diabetes
DOI: 10.1111/cxo.12318
ISSN: 1444-0938
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 06 Jul 2016 23:07
Last Modified: 21 Jul 2016 21:56

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