Longitudinal assessment of inflammatory factors in samples from patients with chronic leg ulcers
Stupar, Dario (2016) Longitudinal assessment of inflammatory factors in samples from patients with chronic leg ulcers. PhD thesis, Queensland University of Technology.
Chronic leg ulcers are a major health problem that affect 1-3% of adults over 65 and are a financial burden on healthcare systems worldwide. In this study biochemical assays were performed on sequential samples collected from both healing and non-healing ulcers. The results demonstrated that inflammatory resolution was necessary for ulcers to heal. Interestingly, in healing ulcers, proteins associated with dampening inflammation did not change over time whilst those keeping the wound in an inflammatory state decreased, suggesting an alternative mechanism for resolution of inflammation.
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|Item Type:||QUT Thesis (PhD)|
|Supervisor:||Upton, Zee, Murray, Rachael, Shooter, Gary, & Finlayson, Kathleen|
|Keywords:||Chronic leg ulcers, Wound healing, Inflammation, Inflammasome, Metabolomics, Mass spectrometry, Cytokines, Chemokines|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Institution:||Queensland University of Technology|
|Deposited On:||19 Jul 2016 23:03|
|Last Modified:||19 Jul 2016 23:03|
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