Increased endothelin and creatine kinase after electrical stimulation of paraplegic muscle

Robergs, R.A., Appenzeller, O., Qualls, C., Aisenbrey, J., Krauss, J., Kopriva, L., & DePaepe, J. (1993) Increased endothelin and creatine kinase after electrical stimulation of paraplegic muscle. Journal of Applied Physiology, 75(6), pp. 2400-2405.

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Abstract

The purpose of this study was to assess changes in creatine kinase (CK) and endothelin (ET) in individuals with spinal cord injury (SCI) after computerized functional electrical stimulation leg ergometry (CFES LE). Eight subjects (7 male and 1 female) with complete spinal cord lesions (C7 to L1) completed zero-loaded CFES LE tests at baseline, after 3, 6, and 12 wk of CFES LE training (30 min, 3 times/wk), and also after detraining (DT) (n = 5). Venous blood samples were drawn 24, 48, and 72 h after CFES LE for measurement of ET and CK. The CK response was largest (peak CK) 72 h after baseline tests (28.2 ± 6.0 to 895.7 ± 345.9 ktals/l) and was no different from baseline by weeks 3, 6, and 12. After DT, CK was similar before and after CFES LE (153.8 ± 19.0 and 189.7 ± 34.5 ktals/l, respectively). CFES LE also significantly increased peak ET after baseline (from 11.7 ± 1.5 to 18.0 ± 2.5 pg/ml). During the subsequent training, peak ET remained significantly higher than the baseline value at weeks 3, 6, and 12 (20.2 ± 1.8, 18.0 ± 1.1, and 16.9 ± 2.2 pg/ml, respectively). After DT, peak ET increased significantly from 9.3 ± 1.2 to 15.4 ± 2.0 pg/ml. During training, a significant relationship (r = 0.44) existed between ln peak CK activity and peak ET. In summary, the increase in circulating ET in spinal cord-injured individuals may have implications for baroreceptor function and therefore blood pressure control in SCI. Further research into CFES LE, ET, and baroreceptor function in SCI is warranted.

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5 citations in Web of Science®

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ID Code: 96691
Item Type: Journal Article
Refereed: Yes
Keywords: creatine kinase; endothelin, adult; article; blood pressure regulation; body position; clinical article; electrostimulation; enzyme activity; female; human; hypotension; male; muscle atrophy; muscle excitation; muscle spasm; paraplegia; pressoreceptor; priority journal; spinal cord i, Adult; Blood Pressure; Creatine Kinase; Electric Stimulation; Endothelins; Ergometry; Female; Heart Rate; Human; Male; Muscles; Paraplegia; Support, Non-U.S. Gov't
ISSN: 8750-7587
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Exercise & Nutrition Sciences
Copyright Owner: Copyright 1993 the American Physiological Society
Deposited On: 07 Jul 2016 06:38
Last Modified: 09 Aug 2016 00:51

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