Metabolic acidosis and fatigue: Where to from here?
Robergs, Robert A. & Kennedy, D. (2011) Metabolic acidosis and fatigue: Where to from here? In Marino, Frank E. (Ed.) Regulation of Fatigue in Exercise. Nova Science Publishers, Inc., pp. 41-61.
For the last 35 years the central focus of acidosis has been on lactic acid or lactate as being the cause of acidosis and acidosis being the cause of fatigue during intense exercise. Unfortunately, causation has been implied from correlation. The organic chemistry of the lactate dehydrogenase reaction clearly demonstrates the error of the development of metabolic acidosis from lactate production. This is not to detract from the significant development of acidosis during intense exercise. However, the assumed negative effect of acidosis on contractile failure is also called into question. The purpose of this review and commentary is to reflect on past research that has investigated the role of acidosis in fatigue, provide extensive evidence from the record of prior and current 31P MRS research on muscle acidosis during exercise and recovery and provide further insight into proton balance during muscle energy catabolism based on computations of multiple competing cation and pH-dependent proton stoichiometry. Finally, we suggest the role of acidosis in fatigue may have a greater effect outside of the cell.
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|Item Type:||Book Chapter|
|Copyright Owner:||2011 Nova Publishers|
|Deposited On:||26 Jul 2016 05:08|
|Last Modified:||27 Jul 2016 04:22|
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