Estradiol effects on the growth hormone/insulin-like growth factor-1 axis in amenorrheic athletes
Waters, Debra L., Dorin, Richard I., Qualls, Clifford R., Ruby, Brent C., Baumgartner, Richard N., & Robergs, Robert A. (2003) Estradiol effects on the growth hormone/insulin-like growth factor-1 axis in amenorrheic athletes. Applied Physiology, Nutrition and Metabolism, 28(1), pp. 64-78.
Disruption of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis has been reported and studied in menopause, hypothalamic amenorrhea, and anorexia nervosa, but not in weight-stable amenorrheic athletes. We investigated the effects of short-term transdermal estradiol on basal and exercise-stimulated serum GH, IGF-1, and associated binding proteins (IGFBP-1 and IGFBP-3) in seven weight-stable female amenorrheic athletes with percentage body fats greater that 12. Each subject received a 72h placebo patch followed by 144h of transdermal estradiol. Serum samples for GH, IGF-1, IGFBP-1, and IGFBP-3 were obtained at baseline (t1), 72hr (t2), 144hr (t3), and during three 90-minute trials of aerobic exercise. Basal, and exercise GH, 1GF-1, and IGFBP-1 were not different between trials. Baseline IGFBP-3 decreased from t1 to t2 (p = 0.04) and serum free fatty acids increased from t1 to t2, and t1 to t3 (p = 0.04, and 0.02 respectively). These findings differ from postmenopausal women, and women having weightloss-associated amenorrhea, suggesting that estrogen, exercise, and nutritional deficiencies may have independent effects on the GH/IGF-1 axis.
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|Item Type:||Journal Article|
|Keywords:||estradiol; fatty acid; growth hormone; somatomedin binding protein 1; somatomedin binding protein 3; somatomedin C; estradiol; fatty acid; growth hormone; somatomedin binding protein 1; somatomedin binding protein 3; somatomedin C, adult; amenorrhea; article; body fat; clinical article; controlled study; drug effect; estradiol blood level; estrogen activity; exercise test; fatty acid blood level; female; growth hormone blood level; human; insulin like activity; nutritional deficienc, Administration, Cutaneous; Amenorrhea; Analysis of Variance; Estradiol; Exercise; Fatty Acids, Nonesterified; Female; Growth Hormone; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Exercise & Nutrition Sciences
|Deposited On:||25 Jul 2016 02:16|
|Last Modified:||25 Jul 2016 02:16|
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