Synthesis and on-demand gelation of multifunctional poly(ethylene glycol)-based polymers

Sokolovskaya, Ekaterina, Barner, Leonie, Braese, Stefan, & Lahann, Joerg (2014) Synthesis and on-demand gelation of multifunctional poly(ethylene glycol)-based polymers. Macromolecular Rapid Communications, 35(8), pp. 780-786.

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Abstract

The synthesis of a novel photoreactive poly(ethylene glycol) (PEG)-based polymer with caged carbonyl groups is reported. We further demonstrate its use for the on-demand fabrication of hydrogels. For rapid gelation, a hydrazide-functionalized PEG is used as the second component for the hydrogel preparation. The photoreactive PEG-based polymer is designed for controlled cleavage of the protecting groups upon exposure to UV light releases free aldehyde moieties, which readily react with hydrazide groups in situ. This hydrogel system may find applications in controlled release drug delivery applications, when combined with in situ gelation. Furthermore, the possibility of forming gels specifically upon UV irradiation gives an opportunity for 3D fabrication of degradable scaffolds.

Impact and interest:

4 citations in Scopus
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4 citations in Web of Science®

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16 since deposited on 26 Jul 2016
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ID Code: 97470
Item Type: Journal Article
Refereed: Yes
Keywords: aldehydes; crosslinking; hydrogel; photochemistry; poly(ethylene glycol)
DOI: 10.1002/marc.201300909
ISSN: 1521-3927
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Deposited On: 26 Jul 2016 22:46
Last Modified: 01 Aug 2016 17:17

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