Controlled growth of protein resistant PHEMA brushes via S-RAFT polymerization

Zamfir, Mirela, Rodriguez-Emmenegger, Cesar, Bauer, Stella, Barner, Leonie, Rosenhahn, Axel, & Barner-Kowollik, Christopher (2013) Controlled growth of protein resistant PHEMA brushes via S-RAFT polymerization. Journal of Materials Chemistry B, 1(44), pp. 6027-6034.

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The reversible addition-fragmentation chain transfer polymerization of 2-hydroxyethyl methacrylate (HEMA) from surfaces (S-RAFT) using an R-group-attached chain transfer agent (CTA) is presented. The approach was exploited for the efficient preparation of well-defined PHEMA brushes of up to 50 nm thickness in a controlled fashion without using any cytotoxic catalyst. The chemical composition, morphology and wettability of the samples were assessed by X-ray photoelectron spectroscopy, atomic force microscopy and water contact angle measurements, while the growth kinetics were studied by monitoring the dry thickness via spectroscopic ellipsometry. The mechanism and kinetics of the RAFT polymerization on the surface-in the presence of a sacrificial CTA and of solvent mixtures with different polarities-were investigated. A marked effect of the concentration of the sacrificial CTA on the kinetics was observed. Importantly -and for the first time -the living PHEMA brushes were exploited as macroRAFT agents for chain extension, and thicknesses up to 70 nm were achieved. The prepared PHEMA brushes were challenged with protein solutions demonstrating their resistance to fouling.

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22 citations in Scopus
23 citations in Web of Science®
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ID Code: 97475
Item Type: Journal Article
Refereed: Yes
DOI: 10.1039/c3tb20880j
ISSN: 2050-750X
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Facilities: Central Analytical Research Facility
Deposited On: 26 Jul 2016 23:22
Last Modified: 01 Aug 2016 00:55

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