A facile route to boronic acid functional polymeric microspheres via epoxide ring opening
Vogt, Andrew P., Trouillet, Vanessa, Greiner, Alexandra M., Kaupp, Michael, Geckle, Udo, Barner, Leonie, Hofe, Thorsten, & Barner-Kowollik, Christopher (2012) A facile route to boronic acid functional polymeric microspheres via epoxide ring opening. Macromolecular Rapid Communications, 33(13), pp. 1108-1113.
Boronic acid-functionalized microspheres are prepared for the first time via mild epoxide ring opening based on porous cross-linked polymeric microspheres (diameter similar to 10 mu m, porosity similar to 1000 angstrom). Quantitative chemical analysis by XPS and EA evidences that there is a greater functionalization with boronic acid when employing a sequential synthetic method [1.7 atom% boron (XPS); 1.12 wt% nitrogen (EA)] versus a one-pot synthetic method [0.2 atom% boron (XPS); 0.60 wt% nitrogen (EA)] yielding grafting densities ranging from approximately 2.5 molecules of boronic acid per nm2 to 1 molecule of boronic acid per nm2, respectively. Furthermore, the boronic acid-functionalized microspheres are conjugated with a novel fluorescent glucose molecule demonstrating a homogeneous spatial distribution of boronic acid.
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|Item Type:||Journal Article|
|Keywords:||boronic acid; epoxide ring opening; glucose FITC; porous polymer microspheres; surface modification|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Facilities:||Central Analytical Research Facility|
|Copyright Owner:||Copyright 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim|
|Deposited On:||26 Jul 2016 22:53|
|Last Modified:||29 Jul 2016 01:25|
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