A facile route to boronic acid functional polymeric microspheres via epoxide ring opening

Vogt, Andrew P., Trouillet, Vanessa, Greiner, Alexandra M., Kaupp, Michael, Geckle, Udo, Barner, Leonie, Hofe, Thorsten, & Barner-Kowollik, Christopher (2012) A facile route to boronic acid functional polymeric microspheres via epoxide ring opening. Macromolecular Rapid Communications, 33(13), pp. 1108-1113.

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Boronic acid-functionalized microspheres are prepared for the first time via mild epoxide ring opening based on porous cross-linked polymeric microspheres (diameter similar to 10 mu m, porosity similar to 1000 angstrom). Quantitative chemical analysis by XPS and EA evidences that there is a greater functionalization with boronic acid when employing a sequential synthetic method [1.7 atom% boron (XPS); 1.12 wt% nitrogen (EA)] versus a one-pot synthetic method [0.2 atom% boron (XPS); 0.60 wt% nitrogen (EA)] yielding grafting densities ranging from approximately 2.5 molecules of boronic acid per nm2 to 1 molecule of boronic acid per nm2, respectively. Furthermore, the boronic acid-functionalized microspheres are conjugated with a novel fluorescent glucose molecule demonstrating a homogeneous spatial distribution of boronic acid.

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6 citations in Web of Science®

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ID Code: 97477
Item Type: Journal Article
Refereed: Yes
Keywords: boronic acid; epoxide ring opening; glucose FITC; porous polymer microspheres; surface modification
DOI: 10.1002/marc.201200144
ISSN: 1022-1336
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Facilities: Central Analytical Research Facility
Copyright Owner: Copyright 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Deposited On: 26 Jul 2016 22:53
Last Modified: 29 Jul 2016 01:25

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