Surface modification of polymeric microspheres using glycopolymers for biorecognition

Pfaff, Andre, Barner, Leonie, Mueller, Axel H.E., & Granville, Anthony M. (2011) Surface modification of polymeric microspheres using glycopolymers for biorecognition. European Polymer Journal, 47(4), pp. 805-815.

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We report the synthesis and characterization of sugar-containing microspheres consisting of poly(divinylbenzene) (PDVB) cores onto which chains of galactose- or mannose-bearing polymers have been grafted. PDVB particles prepared by distillation polymerization with a diameter of 2.4 mu m containing residual surface vinyl groups were used as starting material. “Grafting from”, “grafting through” and “grafting to” techniques were performed and special interest was laid towards the resulting grafting densities. The surface modification via “grafting from” was conducted by reversible addition fragmentation chain transfer (RAFT) polymerization directly from the surface, whereas thiol-ene chemistry was used to affix glycopolymer chains onto the particle surface. The resulting sugar-covered microspheres were analyzed towards their protein recognition activity with a series of lectins.

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35 citations in Scopus
34 citations in Web of Science®
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ID Code: 97483
Item Type: Journal Article
Refereed: Yes
Additional Information: Speical issue for "Designer polymers: Controlled synthesis, structure-property relationships and applications (Dedicated to Professor Nikos Hadjichristidis in recognition of his contribution to polymer science)"
Keywords: Reversible addition fragmentation chain transfer (RAFT) polymerization; Glycopolymer; Microspheres; Thiol-ene reaction
DOI: 10.1016/j.eurpolymj.2010.09.020
ISSN: 0014-3057
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 28 Jul 2016 02:03
Last Modified: 03 Aug 2016 04:31

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