Changes in tissue diffusion and anisotropy following mechanical loading of ovine annulus fibrosus: A pilot study using magnetic resonance imaging

Little, J. Paige, Tourell, Monique C., Momot, Konstantin I., & Pearcy, Mark J. (2016) Changes in tissue diffusion and anisotropy following mechanical loading of ovine annulus fibrosus: A pilot study using magnetic resonance imaging. In 27th Annual Scientific Meeting of the Spine Society of Australia, 8-10 April 2016, Melbourne, Vic. (Unpublished)

Abstract

The current pilot study sought to explore the functional micro-mechanics of the anulus fibrosus using both imaging and experimental methods, in order to better understand the underlying mechanisms which govern the interplay between disc mechanical function and microstructure. A comparison of DTI of anulus fibrosus samples before and after mechanical testing showed clear changes in diffusivity, indicating the tissue becomes more anisotropic following mechanical testing. This increase in anisotropy is possibly due to the collagen fibres becoming more aligned.

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ID Code: 97530
Item Type: Conference Item (Presentation)
Refereed: Yes
Additional URLs:
Keywords: anulus fibrosis, disc microstructure, ovine, vertebral disc, magnetic resonance imaging, diffusion tensor imaging, water diffusion, diffusion anisotropy, collagen fibres
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2016 The Author(s)
Deposited On: 19 Jul 2016 22:26
Last Modified: 20 Jul 2016 22:00

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