The multifocal on- and off-responses in the human diabetic retina

Lung, Jenny C.Y., Swann, Peter G., & Chan, Henry H.L (2016) The multifocal on- and off-responses in the human diabetic retina. PLoS ONE, 11(5), Article Number-e0155071.

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The characteristics of the on- and off-responses in the human diabetic retina by a “long-duration” multifocal electroretinogram (mfERG) paradigm were investigated. Changes in the retinal antagonistic interaction were also evaluated in the early stage of diabetes mellitus (DM). Twenty type II diabetic patients with no or mild non-proliferative diabetic retinopathy (NPDR) and twenty-one age-matched healthy controls were recruited for “long-duration” mfERG measurements. A 61-hexagon mfERG stimulus was displayed under two chromatic conditions (white/black and blue/black) at matched luminance. The amplitudes and implicit times of the on-response components (N1, P1 and N2) and off-response (P2) components were analysed. The blue stimulation generally triggered greater mfERG amplitudes in P1, N2 and P2 (p<0.05) than those from white stimulation in both control and diabetic groups. The diabetic group showed significantly greater N2 amplitude than the controls under white stimulation in mid-retinal regions (Rings 2 and 4) (p<0.05). When the stimulus was changed from white to blue, the diabetic group showed a smaller percentage change in N2 amplitude than the controls in peripheral retinal region (Ring 5) (p<0.02). When a stimulus is changed from white (broad-band spectral stimulation) to blue (narrow-band spectral stimulation), a decrease in the involvement of lateral antagonism would be expected. The larger amplitude of the on-response component (N2) in the diabetic patients suggested an imbalance of lateral antagonism, and the lesser percentage change of N2 amplitude in the diabetic group may indicate an impairment of the cross-talk at the middle retinal level in early stages of DM.

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ID Code: 97542
Item Type: Journal Article
Refereed: Yes
DOI: 10.1371/journal.pone.0155071
ISSN: 1932-6203
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2016 Lung et al
Copyright Statement: This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are
Deposited On: 20 Jul 2016 23:54
Last Modified: 22 Jul 2016 04:35

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