The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients

Menon, Saras, Nasir, Bushra, Avgan, Nesli, Ghassabian, Sussan, Oliver, Christopher, Lea, Rodney A., Smith, Maree, & Griffiths, Lyn (2016) The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. The Journal of Headache and Pain, 17(1).

View at publisher (open access)


Background: Migraine is a common neurovascular condition that may be linked to hyperhomocysteinemia. We have previously provided evidence that reduction of homocysteine with a vitamin supplementation can reduce the occurrence of migraine in women. The current study examined the occurrence of migraine in response to vitamin supplementation with a lower dose of folic acid. Methods: This was a 6 month randomised, double blinded placebo controlled trial of daily vitamin supplementation containing 1 mg of folic acid, 25 mg of Vitamin B6 and Vitamin B12, on reduction of homocysteine and the occurrence of migraine in 300 female patients diagnosed with migraine with aura. Results: Vitamin supplementation with 1 mg of folic acid, did not significantly decrease homocysteine levels (P = 0.2). The treatment group did not show a significant decrease in the percentage of participants with high migraine disability, severity or frequency at the end of the 6 month intervention (P > 0.1). Conclusion: 1 mg of folic acid in combination with vitamin B6 and B12 is less effective in reducing migraine associated symptoms compared to the previously tested dosage of 2 mg folic acid in combination with 25 mg of vitamin B6 and 400 μg of vitamin B12. © 2016, The Author(s).

Impact and interest:

3 citations in Scopus
3 citations in Web of Science®
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

5 since deposited on 21 Jul 2016
5 in the past twelve months

Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 97578
Item Type: Journal Article
Refereed: Yes
Keywords: Folate; Folic acid; Migraine; Vitamin B12; Vitamin B6
DOI: 10.1186/s10194-016-0652-7
ISSN: 1129-2377
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: The authors
Copyright Statement: Springer-Verlag
Deposited On: 21 Jul 2016 06:42
Last Modified: 28 Jun 2017 05:01

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page