The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients

Menon, Saras, Nasir, Bushra, Avgan, Nesli, Ghassabian, Sussan, Oliver, Christopher, Lea, Rodney A., Smith, Maree, & Griffiths, Lyn (2016) The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. The Journal of Headache and Pain, 17(1).

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Abstract

Background: Migraine is a common neurovascular condition that may be linked to hyperhomocysteinemia. We have previously provided evidence that reduction of homocysteine with a vitamin supplementation can reduce the occurrence of migraine in women. The current study examined the occurrence of migraine in response to vitamin supplementation with a lower dose of folic acid. Methods: This was a 6 month randomised, double blinded placebo controlled trial of daily vitamin supplementation containing 1 mg of folic acid, 25 mg of Vitamin B6 and Vitamin B12, on reduction of homocysteine and the occurrence of migraine in 300 female patients diagnosed with migraine with aura. Results: Vitamin supplementation with 1 mg of folic acid, did not significantly decrease homocysteine levels (P = 0.2). The treatment group did not show a significant decrease in the percentage of participants with high migraine disability, severity or frequency at the end of the 6 month intervention (P > 0.1). Conclusion: 1 mg of folic acid in combination with vitamin B6 and B12 is less effective in reducing migraine associated symptoms compared to the previously tested dosage of 2 mg folic acid in combination with 25 mg of vitamin B6 and 400 μg of vitamin B12. © 2016, The Author(s).

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3 citations in Scopus
3 citations in Web of Science®
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ID Code: 97578
Item Type: Journal Article
Refereed: Yes
Keywords: Folate; Folic acid; Migraine; Vitamin B12; Vitamin B6
DOI: 10.1186/s10194-016-0652-7
ISSN: 1129-2377
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: The authors
Copyright Statement: Springer-Verlag
Deposited On: 21 Jul 2016 06:42
Last Modified: 28 Jun 2017 05:01

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