Executive function in adolescents with PKU and their siblings: Associations with biochemistry

Sharman, R., Sullivan, K., Young, R., & McGill, J. (2015) Executive function in adolescents with PKU and their siblings: Associations with biochemistry. Molecular Genetics and Metabolism Reports, 4, pp. 87-88.

PDF (156kB)
Available under License Creative Commons Attribution 4.0.

View at publisher (open access)


Previous research shows consistent and marked executive function impairment in children with early and continuously treated phenylketonuria. This between groups analysis (phenylketonuria group vs sibling controls) found no significant differences in executive function (although adolescents with phenylketonuria performed slightly worse than their siblings). Biochemical relationships with executive function were confined to long-term measures of high phenylalanine:tyrosine ratio exposure, as well as tyrosine exposure independent of phenylalanine. This study suggests that early and continuously treated PKU results in non-significant EF differences (compared to siblings), although the influence of long-term exposure to poorer metabolic control is still evident.

Impact and interest:

2 citations in Scopus
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

8 since deposited on 27 Jul 2016
8 in the past twelve months

Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 97662
Item Type: Journal Article
Refereed: Yes
Keywords: Phenylketonuria; Adolescents; Phenylalanine:tyrosine ratio; Executive function; Dopamine
DOI: 10.1016/j.ymgmr.2015.08.001
ISSN: 2214-4269
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Psychology & Counselling
Deposited On: 27 Jul 2016 01:22
Last Modified: 11 Apr 2017 01:45

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page