Novel dual-acting nitroxide-based hybrid antioxidants

Thomas, Komba (2016) Novel dual-acting nitroxide-based hybrid antioxidants. PhD thesis, Queensland University of Technology.


This project employed a rational drug design and development approached to make hybrid dual-acting antioxidants as potential medications for managing chronic inflammation and oxidative stress-related diseases such as arthritis and Parkinson disease. The approach (pharmacophore hybridization strategy) combined various nitroxide compounds with known drugs - mainly the NSAID and sympathomimetic stimulants class of drugs. The hybrid compounds developed in this project displayed promising therapeutic actions as antioxidant, anti-inflammatory and anticancer agents.

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ID Code: 97691
Item Type: QUT Thesis (PhD)
Supervisor: Bottle, Steven & Fairfull-Smith, Kathryn
Keywords: Nitroxides, Antioxidant, Catechols, Oxidative Stress, Chronic Inflammation, Paramagnetic Broadening, Site Directed Spin Label, Synthesis, Schöllkopf, Nonsteroidal Anti-inflammatory Drugs, Pharmacophore Hybridization
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 09 Aug 2016 01:21
Last Modified: 11 Aug 2016 02:55

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