Novel dual-acting nitroxide-based hybrid antioxidants
Thomas, Komba (2016) Novel dual-acting nitroxide-based hybrid antioxidants. PhD thesis, Queensland University of Technology.
This project employed a rational drug design and development approached to make hybrid dual-acting antioxidants as potential medications for managing chronic inflammation and oxidative stress-related diseases such as arthritis and Parkinson disease. The approach (pharmacophore hybridization strategy) combined various nitroxide compounds with known drugs - mainly the NSAID and sympathomimetic stimulants class of drugs. The hybrid compounds developed in this project displayed promising therapeutic actions as antioxidant, anti-inflammatory and anticancer agents.
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|Item Type:||QUT Thesis (PhD)|
|Supervisor:||Bottle, Steven & Fairfull-Smith, Kathryn|
|Keywords:||Nitroxides, Antioxidant, Catechols, Oxidative Stress, Chronic Inflammation, Paramagnetic Broadening, Site Directed Spin Label, Synthesis, Schöllkopf, Nonsteroidal Anti-inflammatory Drugs, Pharmacophore Hybridization|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Institution:||Queensland University of Technology|
|Deposited On:||09 Aug 2016 01:21|
|Last Modified:||11 Aug 2016 02:55|
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