Clinical implications of circulating tumor cells of breast cancer patients: Role of epithelial-mesenchymal plasticity
McInnes, Linda M., Jacobson, Natalie, Redfern, Andrew, Dowling, Anthony, Thompson, Erik W., & Saunders, Christobel M. (2015) Clinical implications of circulating tumor cells of breast cancer patients: Role of epithelial-mesenchymal plasticity. Frontiers in Oncology, 5, Article Number-42.
There is increasing interest in circulating tumor cells (CTCs) due to their purported role in breast cancer metastasis, and their potential as a 'liquid biopsy' tool in breast cancer diagnosis and management. There are, however, questions with regards to the reliability and consistency of CTC detection and to the relationship between CTCs and prognosis, which is limiting their clinical utility. There is increasing acceptance that the ability of CTCs to alter from an epithelial to mesenchymal phenotype plays an important role in determining the metastatic potential of these cells. This review examines the phenotypic and genetic variation, which has been reported within CTC populations. Importantly, we discuss how the detection and characterization of CTCs provides additional and often differing information from that obtained from the primary tumor, and how this may be utilized in determining prognosis and treatment options. It has been shown for example that hormone receptor status often differs between the primary tumor and CTCs, which may help to explain failure of endocrine treatment. We examine how CTC status may introduce alternative treatment options and also how they may be used to monitor treatment. Finally, we discuss the most interesting current clinical trials involving CTC analysis and note further research that is required before the breast cancer "liquid biopsy" can be realised.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.
|Item Type:||Journal Article|
|Keywords:||Breast cancer, Circulating tumor cells, Clinical application, Epithelial mesenchymal transition, Metastasis, aldehyde dehydrogenase isoenzyme 1, CD45 antigen, cell adhesion molecule, epidermal growth factor receptor 2, estrogen receptor, Hermes antigen, Ki 67 antigen, lapatinib, progesterone receptor, trastuzumab, uvomorulin, antibiotic resistance, Article, cancer growth, cell adhesion, cell invasion, cell isolation, cell proliferation, cellular, subcellular and molecular biological phenomena and functions, circulating tumor cell, clinical assessment tool, clinical decision making, genetic variability, human, immunofluorescence test, meta analysis (topic), multicenter study (topic), overall survival, phase 3 clinical trial (topic), phenotype, protein expression, randomized controlled trial (topic)|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||2015 McInnes, Jacobson, Redfern, Dowling , Thompson and Saunders.|
|Copyright Statement:||This is an open-access article distributed under the terms of the Creative Commons
Attribution License (CC BY). The use, distribution or reproduction in other forums is
permitted, provided the original author(s) or licensor are credited and that the original
publication in this journal is cited, in accordance with accepted academic practice. No
use, distribution or reproduction is permitted which does not comply with these terms.
|Deposited On:||31 Jul 2016 22:39|
|Last Modified:||02 Aug 2016 04:45|
Repository Staff Only: item control page