Proteoglycans: Potential agents in mammographic density and the associated breast cancer risk

Shawky, Michael S., Ricciardelli, Carmela, Lord, Megan, Whitelock, John M., Ferro, Vito, Britt, Kara, & Thompson, Erik W. (2015) Proteoglycans: Potential agents in mammographic density and the associated breast cancer risk. Journal of Mammary Gland Biology and Neoplasia, 20(3), pp. 121-131.

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Abstract

Although increased mammographic density (MD) has been well established as a marker for increased breast cancer (BC) risk, its pathobiology is far from understood. Altered proteoglycan (PG) composition may underpin the physical properties of MD, and may contribute to the associated increase in BC risk. Numerous studies have investigated PGs, which are a major stromal matrix component, in relation to MD and BC and reported results that are sometimes discordant. Our review summarises these results and highlights discrepancies between PG associations with BC and MD, thus serving as a guide for identifying PGs that warrant further research towards developing chemo-preventive or therapeutic agents targeting pre-invasive or invasive breast lesions, respectively. © 2015, Springer Science+Business Media New York.

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ID Code: 97713
Item Type: Journal Article
Refereed: Yes
Keywords: Breast cancer, Extracellular matrix, Glypican, Heparanase, Mammographic density, Perlecan, Proteoglycans, Syndecan, Versican, aggrecan, biglycan, cell surface proteoglycan, decorin, estrogen receptor, glypican 1, glypican 3, hyaluronic acid, leucine rich proteoglycan, lumican, modular proteoglycan, proteoglycan, serglycin, syndecan 1, syndecan 2, syndecan 3, syndecan 4, toll like receptor 2, toll like receptor 4, unclassified drug, amino terminal sequence, angiogenesis, breast carcinogenesis, breast density, cancer recurrence, cancer risk, cancer survival, carboxy terminal sequence, disease association, down regulation, gene overexpression, human, luteal phase, macromolecule, nonhuman, Review, upregulation
DOI: 10.1007/s10911-015-9346-z
ISSN: 1083-3021
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 31 Jul 2016 22:54
Last Modified: 02 Aug 2016 04:20

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