Severe hypoxia and malnutrition collectively contribute to scar fibroblast inhibition and cell apoptosis

Lynam, Emily C., Xie, Yan, Dawson, Rebecca, McGovern, Jacqui A., Upton, Zee, & Wang, XiQiao (2015) Severe hypoxia and malnutrition collectively contribute to scar fibroblast inhibition and cell apoptosis. Wound Repair and Regeneration, 23(5), pp. 664-671.

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This study aims to investigate whether severe hypoxia and malnutrition in scar tissue play key roles to induce hypertrophic scar regression. And scar-derived fibroblasts were treated with moderate/severe hypoxia and malnutrition to model condition of proliferative and regressive scar (5%O2+5%FCS and 0.5%O2+0.5%FCS), and normoxia with well nutrition as control (10%O2+10%FCS). Our results demonstrated that severe hypoxia and malnutrition resulted in significantly reduced cell viability and collagen production, as well as HIF-1, VEGF, TGF-β1, and Bcl-2 protein expression when compared with control, and cell apoptosis occurred. Therefore, the severe hypoxia and malnutrition in scar tissue contribute to fibroblast inhibition and cell apoptosis, which is correlated with scar regression.

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ID Code: 97837
Item Type: Journal Article
Refereed: Yes
Keywords: Hypoxia, Malnutrition, Fibroblast, Cell viability, Total collagen, Cell apoptosis
DOI: 10.1111/wrr.12343
ISSN: 1067-1927
Divisions: Current > Schools > School of Biomedical Sciences
Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: 2015 by the Wound Healing Society
Deposited On: 01 Aug 2016 23:11
Last Modified: 07 Aug 2016 06:30

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