Magnetic resonance imaging of the anulus fibrosus shows changes in tissue diffusion and anisotropy following mechanical loading: A pilot study in ovine tissue
Tourell, Monique C., Kirkwood, Margaret, Momot, Konstantin I., Pearcy, Mark J., & Little, J. Paige (2016) Magnetic resonance imaging of the anulus fibrosus shows changes in tissue diffusion and anisotropy following mechanical loading: A pilot study in ovine tissue. In Spineweek 2016, 16 -20 May 2016, Singapore. (Unpublished)
Prior investigations of disc mechanics have suggested the existence of a ‘derangement’ strain, whereby loading beyond this strain results in damage to the anulus fibrosus ground substance. The current pilot study sought to explore the functional micro-mechanics of the anulus fibrosus using both imaging and experimental methods, in order to better understand the underlying mechanisms which govern the interplay between disc mechanical function and microstructure. A comparison of MRI diffusion tensor imaging of anulus fibrosus samples before and after mechanical testing showed clear changes in diffusivity, indicating the tissue becomes more anisotropic following mechanical testing. This increase in anisotropy is possibly due to the collagen fibres becoming more aligned.
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|Item Type:||Conference Item (Poster)|
|Keywords:||magnetic resonance imaging, anulus fibrosis, tissue diffusion, anisotropy, mechanical loading, ovine, ovine intervertebral disc, disc mechanics, derangement strain, disc microstructure, diffusion tensor imaging|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||2016 The Authors|
|Deposited On:||02 Aug 2016 22:41|
|Last Modified:||02 Aug 2016 22:41|
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