Multireactive poly(2-oxazoline) nanofibers through electro-spinning with crosslinking on the fly

Kalaoglu-Altan, Ozlem, Verbraeken, Bart, Lava, Kathleen, Gevrek, Tugce, Sanyal, Rana, Dargaville, Tim, De Clerck, Karen, Hoogenboom, Richard, & Sanyal, Amitav (2016) Multireactive poly(2-oxazoline) nanofibers through electro-spinning with crosslinking on the fly. ACS Macro Letters, 5(6), pp. 676-681.

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Crosslinked hydrophilic poly(2-oxazoline)-based nanofibers amenable to facile multi-functionalization are fabricated using alkene-containing poly(2-alkyl-2-oxazoline)s (PAOx) via in situ photo-initiated radical thiol-ene conjugation during electrospinning. The resulting crosslinked nanofibers are demonstrated to be multi-functionalizable using different chemistries as they contain two functional handles, being the alkene moieties from the parent copolymer and the residual thiol groups from the tetra-thiol based crosslinker. While the thiol groups in these nanofibers could be passivated or conjugated to install functional molecules through thiol-maleimide conjugation, the alkene groups could sequentially be modified with thiol-containing molecules using photo-initiated radical thiol-ene reactions. Utilization of the photochemically induced conjugation of thiol-bearing molecules to the alkene groups on the nanofibers is used to obtain functionalization in a spatially controlled manner.

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ID Code: 97879
Item Type: Journal Article
Refereed: Yes
Keywords: hydrogel, poly(2-oxazoline), electrospinning, thiol-ene
DOI: 10.1021/acsmacrolett.6b00188
ISSN: 2161-1653
Subjects: Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > MACROMOLECULAR AND MATERIALS CHEMISTRY (030300)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2016 American Chemical Society
Deposited On: 03 Aug 2016 00:56
Last Modified: 07 Aug 2016 05:16

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