Cost-effectiveness of a pragmatic exercise intervention for women with breast cancer: Results from a randomized controlled trial

Gordon, Louisa G., DiSipio, Tracey, Battistutta, Diana, Yates, Patsy, Bashford, John, Pyke, Chris, Eakin, Elizabeth, & Hayes, Sandra C. (2016) Cost-effectiveness of a pragmatic exercise intervention for women with breast cancer: Results from a randomized controlled trial. Psycho-Oncology. (In Press)

[img] Accepted Version (PDF 170kB)
Administrators only | Request a copy from author

View at publisher



  • To report on the cost-effectiveness of the Exercise for Health trial, comparing an exercise intervention with usual care during and following treatment for women with breast cancer.


  • Women with breast cancer were randomized to an eight-month exercise intervention (involving regular contact with an exercise physiologist over the phone, n=67, or home-delivered face-to-face, n=67) or usual care (n=60) group and were assessed pre-intervention (five weeks post-surgery), mid-intervention (six months post-surgery) and 10 weeks post-intervention (12 months post-surgery). The benefit measures were ‘number of improvers’ in quality of life (QoL; FACT-B+4) and quality-adjusted life years (QALYs; EQ-5D-3L). Data on provider, patient and government costs were used to consider two cost scenarios: 1) a service provider model and, 2) a private model.


  • There were 69 improvers in the intervention group compared with 21 in the usual care group (odds ratio 2.09, 95% CI: 1.08, 4.01, p=0.033). The incremental cost per improver was AU$2,282-$2,644. QALY gain for the intervention group versus the usual care group was 0.009, with incremental cost per QALY gain for model one and two being AU$105,231 and AU$90,842, respectively. However, sensitivity analyses indicate that incremental cost per QALY gained was volatile to EQ-5D-3L weights.


  • Findings suggest that a pragmatic exercise intervention yields more women with markedly improved QoL after breast cancer than usual care and may be cost-effective. The results are less certain in terms of incremental cost per QALYs, however this may be an inappropriate measure for reflecting exercise benefit for women with breast cancer.

Impact and interest:

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 97916
Item Type: Journal Article
Refereed: Yes
Keywords: cost-effectiveness, exercise intervention, breast cancer, oncology, quality-adjusted life years
DOI: 10.1002/pon.4201
ISSN: 1057-9249
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Nursing
Current > Schools > School of Public Health & Social Work
Copyright Owner: Copyright 2016 John Wiley & Sons, Ltd.
Deposited On: 05 Aug 2016 00:58
Last Modified: 24 Aug 2016 16:43

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page