Changes in corneal Langerhans cell density during the first few hours of contact lens wear

Alzahrani, Yahya, Pritchard, Nicola, & Efron, Nathan (2016) Changes in corneal Langerhans cell density during the first few hours of contact lens wear. Contact Lens and Anterior Eye, 39(4), pp. 307-310.

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To determine the impact of contact lens wear on Langerhans cell density (LCD) in the central cornea over an 8 h period.


Ten participants wore a hydrogel lens in one eye (the experimental eye) for 8 h. The contralateral non-lens-wearing eye served as a control. The central cornea of each eye was examined at the level of the subbasal nerve plexus using a laser scanning corneal confocal microscope, at baseline (prior to lens wear), then every 2 h for 8 h.


At baseline, LCD was 18 ± 19 and 20 ± 19 cells/mm2 in the experimental and control eyes, respectively. In the experimental eye, LCD increased to 36 ± 32 cells/mm2 after 2 h and then decreased gradually to 30 ± 31 cells/mm2 after 6 h. LCD was greater in the experimental eye than the control eye at the 2, 4, 6 and 8 h time points (p < 0.05). LCD remained constant in the control eye throughout the 8 h experiment.


LCD increases two-fold within the first 2 h of lens wear, indicating a rapid, sub-clinical inflammatory response to uncomplicated lens wear.

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ID Code: 97951
Item Type: Journal Article
Refereed: Yes
Keywords: Contact lens, Cornea, Langerhans cells, Laser scanning confocal microscopy
DOI: 10.1016/j.clae.2016.02.008
ISSN: 1367-0484
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2016 British Contact Lens Association. Published by Elsevier Ltd.
Deposited On: 08 Aug 2016 23:35
Last Modified: 29 Aug 2016 16:23

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