Critical sized mandibular defect regeneration in preclinical in vivo models

Brierly, G.I., Tredinnick, S., Lynham, A., & Woodruff, M.A. (2016) Critical sized mandibular defect regeneration in preclinical in vivo models. Current Molecular Biology Reports, 2(2), pp. 83-89.

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Restoration of critical sized defects of the mandible still poses a major problem in the field of Oral and Maxillofacial Surgery. The current gold standard of treatment relies on the use of autologous grafts and therefore, has associated disadvantages such as donor site morbidity and insufficient bone for prosthetic rehabilitation. Recent advances in the fields of bone tissue engineering and distraction osteogenesis provide an alternative treatment modality to restore the aforementioned critical sized defects. These alternative modalities offer patients and clinicians multiple advantages such as decreased morbidity and increased volume of bone for prosthetic restoration. The aim of this review was to evaluate the bone regeneration capacity of bone tissue engineering and distraction osteogenesis in preclinical in vivo animal models against the current gold standard.

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ID Code: 97952
Item Type: Journal Article
Refereed: Yes
Additional Information: Topical Collection on Preclinical Animal Models in Regenerative Medicine
Keywords: Mandible, Regeneration, Animal model, Critical size defect, Scaffold
DOI: 10.1007/s40610-016-0036-4
ISSN: 2198-6428
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2016 Springer
Deposited On: 08 Aug 2016 01:25
Last Modified: 08 Aug 2016 23:48

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