Does glutathione transferase loading into exosomes from prostate cancer cells influence progression?

Sagar, Yashna K. (2016) Does glutathione transferase loading into exosomes from prostate cancer cells influence progression? Masters by Research thesis, Queensland University of Technology.


This project showed that exosomes, small vesicles called released from cells including prostate cancer cells, contain enzymes called glutathione transferases. Glutathione transferase enzymes have roles in drug detoxification and may assist in resistance of prostate cancer cells to chemotherapeutic drugs. In a novel finding, one of the members of this family of enzymes, Glutathione transferase mu, was commonly identified as cargo in prostate cancer cell exosomes. Interestingly, isolated prostate cancer cell exosomes increased resistance to Docetaxel, a common anti-cancer therapeutic drug, when added to treatment medium. Exosomes can be easily isolated from the blood of men with prostate cancer and identification of glutathione transferase enzymes in these may find prognostic use in identifying patients with prostate cancer that might develop resistance.

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ID Code: 98015
Item Type: QUT Thesis (Masters by Research)
Supervisor: Stephenson, Sally-Anne & Herington, Adrian
Keywords: Prostate cancer, Exosomes, Glutathione transferase, Proliferaton, Chemotherapy, Docetaxel
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 05 Sep 2016 00:25
Last Modified: 05 Sep 2016 00:25

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