A systematic review and meta-analysis of prescribing practices of antidepressants in cancer patients
Sanjida, Saira, Janda, Monika, Kissane, David, Shaw, Joanne, Pearson, Sally-Anne, DiSipio, Tracey, & Couper, Jeremy (2016) A systematic review and meta-analysis of prescribing practices of antidepressants in cancer patients. Psycho-Oncology. (In Press)
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- Antidepressants are commonly used for the pharmacological treatment of depression. We aimed to summarise the prevalence of antidepressant prescription to cancer patients, and differences by study or patient characteristics.
- PubMed, Embase, Web of Science, Scopus and psychINFO were searched using keywords ‘psychotropic’, ‘antidepressants’, ‘prescription’ and ‘cancer’. Prevalence of antidepressants, type, dose and follow-up of antidepressants and prescriber details were extracted.
- Overall, 1537 articles between 1979 and February 2015 were found, 38 met the inclusion criteria and were reviewed according to PRISMA guidelines. The prevalence rate of prescribing antidepressants to cancer patients was 15.6% (95% CI= 13.3-18.3). Prescription was significantly less common in studies from Asia (7.4%; 95% CI= 4.3-12.5), more common in female (22.6%; 95% CI= 16-31) or breast cancer patients (22.6%; 95% CI= 16-30.9). Selective serotonin reuptake inhibitors were the most frequently prescribed antidepressants. General practitioners and psychiatrists, followed by oncologists, were identified as the major providers of antidepressant prescriptions to cancer patients. Few studies reported the exact dose, length of time drugs were prescribed for or follow-up regimens.
- There is considerable variation in the prescribing patterns of antidepressants across the world, with few studies reporting robust data on exact dose or follow-up regimens. Prospective studies that monitor antidepressant prescribing, including details of reasons for prescribing and the health care providers involved, dose, change in dose or type of medication and follow-up are needed to ascertain whether patients are being treated optimally and if side effects or drug-drug interactions are identified and managed.
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|Item Type:||Journal Article|
|Keywords:||Cancer, Oncology, Antidepressants, Psychotropic, Prescription|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700)
Australian and New Zealand Standard Research Classification
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
|Copyright Owner:||Copyright 2016 John Wiley & Sons|
|Deposited On:||30 Aug 2016 04:40|
|Last Modified:||06 Sep 2016 16:11|
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