Characterisation of human single-stranded DNA-binding protein 1 (hSSB1) regulation by post-translational modifications

Ashton, Nicholas W. (2016) Characterisation of human single-stranded DNA-binding protein 1 (hSSB1) regulation by post-translational modifications. PhD thesis, Queensland University of Technology.


Human single-stranded DNA-binding protein 1 (hSSB1) is required for the timely repair of double-strand DNA breaks, as well as the stabilisation and restart of stalled replication forks. In this work, evidence is provided that cellular survival in response to replication stress is promoted by dynamic phosphorylation of hSSB1 by the DNA-dependent protein kinase (DNA-PK) and PPP-family protein phosphatases. These data provide insight into the functional regulation of hSSB1 following replication fork disruption.

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ID Code: 98660
Item Type: QUT Thesis (PhD)
Supervisor: Richard, Derek, Paquet, Nicolas, Croft, Laura, & Pollock, Pamela M.
Keywords: Human single-stranded DNA-binding protein 1, Nucleic acid-binding protein 2, OB-fold containing protein 2B, Sensor of single-stranded DNA complex subunit B, DNA-dependent protein kinase (DNA-PK), PPP-family protein phosphatases, Integrator complex subunit 3 (INTS3), hSSB1, NABP2, OBFC2B
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 22 Sep 2016 00:45
Last Modified: 26 Jun 2017 14:46

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