Nucleophosmin: From structure and function to disease development

Box, Joseph K., Paquet, Nicolas, Adams, Mark N., Boucher, Didier, Bolderson, Emma, O’Byrne, Kenneth J., & Richard, Derek J. (2016) Nucleophosmin: From structure and function to disease development. BMC Molecular Biology, 17, Article no. 19.

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Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers.

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ID Code: 98795
Item Type: Journal Article
Refereed: Yes
Keywords: Nucleophosmin (NPM1), DNA repair, Cancer, Apoptosis, Mutation
DOI: 10.1186/s12867-016-0073-9
ISSN: 1471-2199
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2016 The Author(s)
Copyright Statement: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Deposited On: 12 Sep 2016 23:54
Last Modified: 13 Sep 2016 23:53

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