Two-layer red blood cell membrane model using the discrete element method
Barns, Sarah, Sauret, Emilie, Saha, Suvash, Flower, Robert, & Gu, YuanTong (2016) Two-layer red blood cell membrane model using the discrete element method. Applied Mechanics and Materials, 846, pp. 270-275.
The red blood cell (RBC) membrane consists of a lipid bilayer and spectrin-based cytoskeleton, which enclose haemoglobin-rich fluid. Numerical models of RBCs typically integrate the two membrane components into a single layer, preventing investigation of bilayer-cytoskeleton interaction. To address this constraint, a new RBC model which considers the bilayer and cytoskeleton separately is developed using the discrete element method (DEM). This is completed in 2D as a proof-of-concept, with an extension to 3D planned in the future. Resting RBC morphology predicted by the two-layer model is compared to an equivalent and well-established composite (one-layer) model with excellent agreement for critical cell dimensions. A parametric study is performed where area reduction ratio and spring constants are varied. It is found that predicted resting geometry is relatively insensitive to changes in spring stiffness, but a shape variation is observed for reduction ratio changes as expected.
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|Item Type:||Journal Article|
|Keywords:||Red Blood Cell, Biconcave Shape, Two-Layer, Numerical Model|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > INTERDISCIPLINARY ENGINEERING (091500) > Interdisciplinary Engineering not elsewhere classified (091599)
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Facilities:||Central Analytical Research Facility|
|Copyright Owner:||Copyright 2016 Trans Tech Publications Inc.|
|Deposited On:||14 Sep 2016 01:55|
|Last Modified:||20 Sep 2016 01:36|
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