Salivary epigenetic biomarkers in head and neck squamous cell carcinomas

Lim, Yenkai, Sun, Charles Xiaohang, Tran, Peter, & Punyadeera, Chamindie (2016) Salivary epigenetic biomarkers in head and neck squamous cell carcinomas. Biomarkers in Medicine, 10(3), pp. 301-313.

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Abstract

The early detection of head and neck squamous cell carcinoma (HNSCC) continues to be a challenge to the clinician. Saliva as a diagnostic medium carries significant advantages including its close proximity to the region of interest, ease of collection and noninvasive nature. While the identification of biomarkers continues to carry significant diagnostic and prognostic utility in HNSCC, epigenetic alterations present a novel opportunity to serve this purpose. With the developments of novel and innovative technologies, epigenetic alterations are now emerging as attractive candidates in HNSCC. As such, this review will focus on two commonly aberrant epigenetic alterations: DNA methylation and microRNA expression in HNSCC and their potential clinical utility. Identification and validation of these salivary epigenetic biomarkers would not only enable early diagnosis but will also facilitate in the clinical management.

Impact and interest:

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ID Code: 98878
Item Type: Journal Article
Refereed: Yes
Keywords: Head and Neck Cancer, early detection, squamous cell carinoma, HNSCC, saliva, diagnostic, salivary epigenetic biomarkers
DOI: 10.2217/bmm.16.2
ISSN: 1752-0371
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Diagnosis (111202)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Molecular Targets (111207)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2016 Future Medicine Ltd
Deposited On: 16 Sep 2016 00:51
Last Modified: 16 Nov 2016 00:26

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