Biomaterial science meets computational biology

Hutmacher, Dietmar W., Little, J. Paige, Pettet, Graeme J., & Loessner, Daniela (2015) Biomaterial science meets computational biology. Journal of Materials Science: Materials in Medicine, 26(5), Article 185.

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Abstract

There is a pressing need for a predictive tool capable of revealing a holistic understanding of fundamental elements in the normal and pathological cell physiology of organoids in order to decipher the mechanoresponse of cells. Therefore, the integration of a systems bioengineering approach into a validated mathematical model is necessary to develop a new simulation tool. This tool can only be innovative by combining biomaterials science with computational biology. Systems-level and multi-scale experimental data are incorporated into a single framework, thus representing both single cells and collective cell behaviour. Such a computational platform needs to be validated in order to discover key mechano-biological factors associated with cell–cell and cell–niche interactions.

Dietmar W. Hutmacher and J. Paige Little are joint first authors.

Impact and interest:

1 citations in Scopus
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ID Code: 98882
Item Type: Journal Article
Refereed: Yes
Additional Information: Special Issue: ESB 2014
Keywords: cell physiology of organoids, mechanoresponse of cells, systems bioengineering approach, validated mathematical model, new simulation tool, biomaterials science, computational biology, Systems-level experimental data, Multi-scale experimental data, collective cell behaviour, single cells, computational platform, mechano-biological factors associated, cell-niche interactions, cell-cell interactions
DOI: 10.1007/s10856-015-5518-z
ISSN: 1573-4838
Subjects: Australian and New Zealand Standard Research Classification > INFORMATION AND COMPUTING SCIENCES (080000) > COMPUTER SOFTWARE (080300) > Bioinformatics Software (080301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Springer Science+Business Media New York
Deposited On: 16 Sep 2016 00:53
Last Modified: 20 Sep 2016 00:52

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